Reply: Adverse Effects of Long-Acting Beta-Agonists on Airway Hyperresponsiveness
نویسندگان
چکیده
منابع مشابه
Long-Acting Beta Agonists Enhance Allergic Airway Disease
Asthma is one of the most common of medical illnesses and is treated in part by drugs that activate the beta-2-adrenoceptor (β2-AR) to dilate obstructed airways. Such drugs include long acting beta agonists (LABAs) that are paradoxically linked to excess asthma-related mortality. Here we show that LABAs such as salmeterol and structurally related β2-AR drugs such as formoterol and carvedilol, b...
متن کاملWhy are long-acting beta-adrenoceptor agonists long-acting?
The extended duration of bronchodilation due to formoterol and salmeterol greatly exceeds that of short acting beta 2-adrenoceptor agonists, such as salbutamol or terbutaline. This extended duration and their capacity to "reassert" airway smooth muscle relaxation in vitro despite repeated washing has prompted considerable debate on the underlying mechanism(s). The comparative pharmacology, and ...
متن کاملSafety of long-acting beta-agonists.
Beta2-adrenoceptor agonists have been used as bronchodilators in the management of bronchial asthma and chronic obstructive pulmonary disease (COPD); however, there is evidence suggesting that beta2adrenoceptor agonist use may increase morbidity and mortality1. The long term beta-agonists, salmeterol and formeterol were introduced at the time of heightened concern about safety of beta2 agonist ...
متن کاملEffects of long-acting and short-acting beta-agonists on methacholine dose-response curves in asthmatics.
Regular use of short-acting beta-agonists may decrease control of asthma and increase airway responsiveness to bronchoconstrictor stimuli. The aim of this study was to determine the effects of regular treatment with the long-acting beta-agonist, salmeterol, on the methacholine dose-response curve (DRC) in mild-to-moderate asthmatics. Changes in methacholine airway responsiveness were measured i...
متن کاملSome pharmacodynamic aspects on long-acting beta-adrenoceptor agonists.
1. Formoterol and salmeterol are the first members of a new generation of long-acting beta(2)-adrenoceptor agonists for inhalation. The discovery of the long effect duration of formoterol was made by chance, while the development of salmeterol appeared to follow a purposeful research strategy. 2. Preclinical evaluation predictive of the clinical duration of effect of long-acting bronchodilators...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2013
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2013-0161le